Alzheimers Disease
Annals of Long-Term Care on the Web is a comprehensive resource for clinical information on geriatric medicine and long-term care as well as Alzheimers Disease. We hope the articles below provide timely information for your practice.
The Role of Alternative Therapies in the Management of Alzheimer?s Disease and Dementia, Part I
Prior to and since the development of prescription pharmacologic therapies for Alzheimer?s disease and dementia, there has been significant interest in and use of alternative therapies by the lay public. To some extent, this is related to the lack of a variety of available classes of therapies and ?cures,? and to some extent, it is related to expense, limited efficacy, and side effects of these prescription agents. Since patients and caregivers often confront the treating physician about efficacy of alternative agents, the practitioner should be knowledgeable and up-to-date on this issue. Part I of this article covers the latest research on alternative therapies such as non-steroidal anti-inflammatory drugs, aspirin, cyclooxygenase-2 inhibitors, vitamins and selegiline, and homocysteine in the management of Alzheimer?s disease and dementia. (Annals of Long-Term Care: Clinical Care and Aging 2005;13[7]:34-41)
June 2005 Cholinesterase Inhibitors Across Stages of Dementia and Cognitive Impairments in the Elderly
Salloway et al12 conducted a randomized, double-blind, placebo-controlled study of donepezil in 270 patients with MCI. A randomized, double-blind, placebo-controlled, 24-month study of galantamine in 1062 patients with MCI aimed to improve cognition and global functioning at 12 months, and to delay conversion to dementia.14 ADAS-Cog/MCI, CDR-SB, and CDR were not statistically significant with use of galantamine versus placebo in improving cognition and function in patients with MCI. Raskind...
Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease
s disease, optimal clinical outcomes for disease management, and care management plans that will maximize treatment outcomes in Alzheimer? Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: A randomized controlled trial.
Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease
Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease March 2004Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease Manju T. Beier, PharmD, FASCP (Chairperson), Elaine R. Peskind, MD, Mark Sey, RPh, CGP, FASCP On November 13, 2003, a symposium was presented on ? s disease, optimal clinical outcomes for disease management, and care management plans that will maximize treatment outcomes in Alzheimer? Estrogen replacement therapy for treatment of ...
Diagnostic Challenges and Treatment Options: Case Presentation on Cognitive Decline and Dementia
The early diagnosis and treatment of Alzheimer?s disease brings benefit to the patient, his or her family, and the caregivers. Slowing or delaying the progression of disease reduces morbidity, improves functional independence, and decreases overall expense. The interface between cardiovascular health and dementia affords even greater opportunity to impact the management of Alzheimer?s disease by recognizing and treating other comorbidities. As we further understand mild cognitive impairment, there may be additional opportunities to intervene even earlier. The authors present the case of a woman with short-term memory loss. (Annals of Long-Term Care: Clinical Care and Aging 2005;13[3]:41-45)
Abstracts from Medical Literature for the Geriatrics Practitioner
S DISEASE This study was an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate-to-severe Alzheimer disease. Arch Neurol 2006;63:49-54. ANTIMICROBIAL URINARY CATHETERS TO PREVENT CATHETER-ASSOCIATED UTI The efficacy of antimicrobial urinary catheters in hospitalized patients is poorly defined. Systematic review: Antimicrobial urinary catheters to prevent catheter-associated urinary tract infection in hospitalized patients.
Cholinergic Therapy for Alzheimer's Disease
Cholinergic Therapy for Alzheimer's Disease Cholinergic Therapy for Alzheimer's Disease By Morgan L. Levy, MD Abstract Cholinergic therapies such as tacrine and donepezil improve memory, language, and praxis (higher-level control of motor function) in Alzheimer's disease. Alzheimer's disease (AD) is the prototypical example, but other syndromes with a cholinergic deficit include dementia with Lewy bodies, Parkinson's disease with dementia, progressive supranuclear palsy with dementia, ...
Comparing Alzheimer?s Disease and Frontotemporal Lobar Degeneration: Implications for Long-Term Care
s Disease and Frontotemporal Lobar Degeneration: Implications for Long-Term Care Special Article: Comparing Alzheimer? s Disease and Frontotemporal Lobar Degeneration: Implications for Long-Term Care - Jennifer Merrilees, RN, MS, and Bruce L. Miller, MD Click here to download full article in PDF format The cognitive impairments and behavioral symptoms associated with dementia have a progressive, negative impact on self-care abilities. s disease (AD), the most common cause of dementia, less ...
Geriatrics Abstracts
Geriatrics Abstracts Geriatrics Abstracts Click here to download full article in PDF Alcohol Use Disorders in Elderly People: Redefining an Age Old Problem in Old Age Alcohol use disorders are common among elderly people and are associated with significant morbidity. Emerging Risk Factors for Atherosclerotic Vascular Disease Atherosclerotic vascular disease is a considerable public health problem. are related to risk of vascular disease, the optimal use of these factors in routine screening...
Executive Control Function and Vascular Disease: Should We Pay More Attention to Frontal System Deficits in Patients With MCI?
Executive Control Function and Vascular Disease: Should We Pay More Attention to Frontal System Deficits in Patients With MCI? Presently, the clinical conundrum includes the initial diagnosis of MCI and the differentiation among the MCI subgroups, such as posterior cortical dementia syndrome (eg, AD), frontal system syndromes, mixed dementia syndromes, and normal aging.13 Several studies have identified MCI subclusters that may eventually lead to the development of diagnostic subgroups. ...
Prior to and since the development of prescription pharmacologic therapies for Alzheimer?s disease and dementia, there has been significant interest in and use of alternative therapies by the lay public. To some extent, this is related to the lack of a variety of available classes of therapies and ?cures,? and to some extent, it is related to expense, limited efficacy, and side effects of these prescription agents. Since patients and caregivers often confront the treating physician about efficacy of alternative agents, the practitioner should be knowledgeable and up-to-date on this issue. Part I of this article covers the latest research on alternative therapies such as non-steroidal anti-inflammatory drugs, aspirin, cyclooxygenase-2 inhibitors, vitamins and selegiline, and homocysteine in the management of Alzheimer?s disease and dementia. (Annals of Long-Term Care: Clinical Care and Aging 2005;13[7]:34-41)
Salloway et al12 conducted a randomized, double-blind, placebo-controlled study of donepezil in 270 patients with MCI. A randomized, double-blind, placebo-controlled, 24-month study of galantamine in 1062 patients with MCI aimed to improve cognition and global functioning at 12 months, and to delay conversion to dementia.14 ADAS-Cog/MCI, CDR-SB, and CDR were not statistically significant with use of galantamine versus placebo in improving cognition and function in patients with MCI. Raskind...
s disease, optimal clinical outcomes for disease management, and care management plans that will maximize treatment outcomes in Alzheimer? Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression: A randomized controlled trial. Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: A randomized controlled trial.
Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease March 2004Optimizing Care Management Plans Across the Spectrum of Alzheimer's Disease Manju T. Beier, PharmD, FASCP (Chairperson), Elaine R. Peskind, MD, Mark Sey, RPh, CGP, FASCP On November 13, 2003, a symposium was presented on ? s disease, optimal clinical outcomes for disease management, and care management plans that will maximize treatment outcomes in Alzheimer? Estrogen replacement therapy for treatment of ...
The early diagnosis and treatment of Alzheimer?s disease brings benefit to the patient, his or her family, and the caregivers. Slowing or delaying the progression of disease reduces morbidity, improves functional independence, and decreases overall expense. The interface between cardiovascular health and dementia affords even greater opportunity to impact the management of Alzheimer?s disease by recognizing and treating other comorbidities. As we further understand mild cognitive impairment, there may be additional opportunities to intervene even earlier. The authors present the case of a woman with short-term memory loss. (Annals of Long-Term Care: Clinical Care and Aging 2005;13[3]:41-45)
S DISEASE This study was an extension of a 28-week, randomized, double-blind, placebo-controlled study of memantine in 252 patients with moderate-to-severe Alzheimer disease. Arch Neurol 2006;63:49-54. ANTIMICROBIAL URINARY CATHETERS TO PREVENT CATHETER-ASSOCIATED UTI The efficacy of antimicrobial urinary catheters in hospitalized patients is poorly defined. Systematic review: Antimicrobial urinary catheters to prevent catheter-associated urinary tract infection in hospitalized patients.
Cholinergic Therapy for Alzheimer's Disease Cholinergic Therapy for Alzheimer's Disease By Morgan L. Levy, MD Abstract Cholinergic therapies such as tacrine and donepezil improve memory, language, and praxis (higher-level control of motor function) in Alzheimer's disease. Alzheimer's disease (AD) is the prototypical example, but other syndromes with a cholinergic deficit include dementia with Lewy bodies, Parkinson's disease with dementia, progressive supranuclear palsy with dementia, ...
s Disease and Frontotemporal Lobar Degeneration: Implications for Long-Term Care Special Article: Comparing Alzheimer? s Disease and Frontotemporal Lobar Degeneration: Implications for Long-Term Care - Jennifer Merrilees, RN, MS, and Bruce L. Miller, MD Click here to download full article in PDF format The cognitive impairments and behavioral symptoms associated with dementia have a progressive, negative impact on self-care abilities. s disease (AD), the most common cause of dementia, less ...
Geriatrics Abstracts Geriatrics Abstracts Click here to download full article in PDF Alcohol Use Disorders in Elderly People: Redefining an Age Old Problem in Old Age Alcohol use disorders are common among elderly people and are associated with significant morbidity. Emerging Risk Factors for Atherosclerotic Vascular Disease Atherosclerotic vascular disease is a considerable public health problem. are related to risk of vascular disease, the optimal use of these factors in routine screening...
Executive Control Function and Vascular Disease: Should We Pay More Attention to Frontal System Deficits in Patients With MCI? Presently, the clinical conundrum includes the initial diagnosis of MCI and the differentiation among the MCI subgroups, such as posterior cortical dementia syndrome (eg, AD), frontal system syndromes, mixed dementia syndromes, and normal aging.13 Several studies have identified MCI subclusters that may eventually lead to the development of diagnostic subgroups. ...